Our NIEHS training grant is focused on understanding how toxicants/cellular stressors perturb cellular signaling pathways/networks, deregulate gene expression and how this contributes to toxicity and disease. The title of our postdoctoral training program, Molecular Pathways to Pathogenesis in Toxicology, reflects the development of a progressive, state-of-the-art interdisciplinary training program focused on signaling pathways in toxicology. Specific environmental-associated human diseases/conditions such as asthma, lung fibrosis, reproductive/endocrine abnormalities, developmental abnormalities and cancer as well as ROS-related toxicity/inflammatory disease conditions will be the focal molecular/cellular research areas. Postdoctoral trainees use sophisticated approaches to accomplish these goals including:
- development and analysis of genetically engineered mouse models
- a systems biology chemical-genetic approach that links small molecule effects to pathways and phenotypes,
- a systems approach using recombinant-inbred mouse intercross strains to identify genes/pathways important in environmentally-induced disease
- chromatin remodeling to study ROS-induced gene expression
- computational biology approaches to cell signaling
- molecular profiling and functional genomic approaches to link phenotypes to specific genes/pathways
- engineered yeast to study by-pass DNA polymerases and genomic instability
- non-mammalian model systems such Medaka, zebrafish and daphnids to study gene function/cellular signaling.
Evidence that the laboratories of our training faculty conduct state-of-the-art research can be found in the high impact journals in which their research has been published, including Nature, Nature Immunology, Nature Medicine, Genes and Development, PNAS, Genome Research, Cell Death and Differentiation, Journal of Cell Biology, Molecular Pharmacology, Cancer Research, Nucleic Acids Research, FASEB Journal, Molecular and Cellular Biology, Oncogene, Journal of Immunology, American Journal of Pathology, Environmental Health Perspectives and Endocrinology. Our program is a fundamental knowledge based program that uses state-of-the-art approaches to delineate the pathways and networks that contribute to toxicity and disease.