Research Areas: Environmental/Molecular, Marine Toxicology
My research focuses on the study of man-made and natural toxins in the marine environment and their effects on the metabolic activities of marine organisms. Biochemical and health effects following exposure to anthropogenic compounds, contaminants and toxins can drastically alter the development, metamorphosis, reproductive capacity or the ability of exposed organisms to utilize nutritional resources. The consequences of exposure may be human health effects related to ecosystem exposure and reduced water quality, declines in available habitat and decreases of vital fisheries (both finfish and shellfish). Current research themes include (1) examination of the molecular and biochemical pathways involved in endocrine production, metabolism and environmental disruption, (2) the effects of anthropogenic exposure on uptake, distribution and metabolism including oxidative stress in marine/estuarine species (3) determining the effects and consequences of exposure to antifouling compounds and booster biocides on non-target species and (4) the characterization of detoxification pathways (cytochrome P450s) in marine species.
Björnsdóttir-Butler, Kristin, Bolton, Greg, Jaykus, Lee-Ann, McClellan-Green, Patricia D., and Green, David P (2010) Development of molecular-based methods for determination of high histamine producing bacteria in fish. Internat. J. Food Microbiol. 139(3): 161-167.
Romano, Jocelyn A., Rittschof, Daniel, McClellan-Green, Patricia and Eric R. Holm (2010). Variation in toxicity of copper pyrithione among populations and families of the barnacle, Balanus amphitrite. Biofouling 26: 341-347.
Blickley, TM, Rittschof, D and P McClellan-Green (2009) Toxicological effects of nanocrystal exposure in teleosts. in Conference Proceedings: International Conference on the Environmental Implications and Applications of Nanotechnology, University of Massachusetts Amherst, June 9-11, 2009, edited by The Environmental Institute, 2009, http://scholarworks.umass.edu/tei, [pp 3-6].
Bjornsdottir, Kristin, Bolton, Gregory E., McClellan-Green, Patricia D., Jaykus, Lee-Ann and David P. Green (2009). Detection of gram-negative histamine producing bacteria in fish: a comparative study. J. Food Protection 72(9): 1987-1991.
Blickley, T. Michelle and Patricia McClellan-Green (2008). Toxicity of Aqueous Fullerene (nC60) in Adult and Larval Fundulus heteroclitus. Environ. Toxicol. Chem. 27: 1964-1971.
Burger, Joanna, Fossi, Cristina, McClellan-Green, Patricia and Edward F. Orlando (2007). Methodologies, bioindicators, and biomarkers for assessing gender-related differences in wildlife exposed to environmental chemicals. Environ. Res. 104: 135-152.
McClellan-Green, Patricia, Romano, Jocelyn and Eva Oberdörster. (2007) Does gender really matter in contaminant exposure? A case for invertebrate risk assessment. Environ. Res. 104: 183-191.
McClellan-Green, Patricia, Romano, Jocelyn and Daniel Rittschof (2006). Imposex Induction in the Mud Snail, Ilyanassa obsoleta By Three Tin Compounds. Bull. Environ. Cont. Toxicol. 76: 581-588.
Oberdörster, Eva, Zhu, Shiqian, Blickley, T. Michelle, McClellan-Green, Patricia and Mary L. Haasch (2006). Ecotoxicology of Carbon-Based Engineered Nanoparticles: Effects of Fullerene (C60) on aquatic organisms. Carbon 44:1112-1120.
Keller, JM; Owens, D; Kucklick, JR; Maier, P; Stender, B; Segars, A; Whitaker, D; McClellan-Green, PD (2006). Abnormal vitellogenin production in vivo and alterations of aromatase activity in vitro due to organochlorine contaminants in sea turtles. NOAA Technical Memorandum NMFS SEFSC [NOAA Tech. Mem. NMFS SEFSC]. no. 536, p. 253.
Keller, Jennifer M., McClellan-Green, Patricia D., Kucklick, John R., Keil, Deborah E. and Margie M. Peden-Adams (2006) Effects of Organochlorine Contaminants on Loggerhead Sea Turtle Immunity: Comparison of a Correlative Field Study and In Vitro Exposure Experiments. Environ. Hlth. Prespec. 114(1): 70-76.
Haasch, Mary L., McClellan-Green, Patricia, and Eva Oberdörster (2005). Consideration of the toxicity of manufactured nanoparticles. In XIX International Winterschool/Euroconference on Electronic Properties of Novel Materials (H. Kuzmany, J. Fink, M. Mehring and S. Roth, eds.), Vol. 786, pp. 586-589. American Institute of Physics (AIP), Kirchberg, Tirol, Austria.
Oberdorster, Eva, Romano, Jocelyn and Patricia McClellan-Green (2005). The neuropeptide APGWamide as a Penis Morphogenic Factor (PMF) in gastropod mollusks. Integrative and Comparative Biology 45 (1): 28-32.
Rittschof, Daniel and Patricia McClellan-Green (2005). Mollusks as Multidisciplinary Models in Environment Toxicology. Mar. Pol. Bull. 50(4): 369-373.
Keller, Jennifer M., McClellan-Green, Patricia D., Lee, A. Michelle, Arendt, Mike D., Maier, Philip P., Segars, Al L., Whitaker, J. David, Keil, Deborah E. and Margie M. Peden-Adams (2005). Mitogen-induced lymphocyte proliferation in loggerhead sea turtles: Comparison of methods and effects of gender, plasma testosterone concentration and body condition on immunity. Vet. Immunol. Immunopath. 103: 269-281.
Keller, Jennifer M., John R. Kucklick, M. Andrew Stamper, Craig A Harms, Patricia McClellan-Green (2004). Are organochlorine contaminants affecting the clinical health of loggerhead sea turtles? Environ. Hlth Perspec. 112(10): 1074-1079.
Keller, J.M., J. R. Kucklick and P. McClellan-Green (2004). Organochlorine Contaminants in Loggerhead Sea Turtle Blood: Extraction Techniques and Distribution among Plasma and Red Blood Cells. Arch. Environ. Contam. Toxicol. 46(2): 254-264.
Keller, J.M., Kucklick, J.R., Harms, C., McClellan-Green, P. (2004). Organochlorine Contaminants in Sea Turtles: Correlations between Whole Blood and Fat. Environ. Toxicol. Chem. 23(3): 726-738.
Keller, Jennifer M. and Patricia McClellan-Green (2004). Effects of organochlorine compounds on cytochrome P450 aromatase activity in an immortal sea turtle cell line. Mar. Environ. Res. 58(2-5): 347-351.