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General Toxicology PhD Concentration

General Toxicology Concentration Description

The General Toxicology Concentration is designed for students who desire a broad toxicology background and do not desire the specificity of the Environmental or the Molecular and Cellular Concentrations. Students electing this option may want to pursue research in more traditional areas of toxicology including fate and metabolism of toxicants, organ and cellular toxicity, endocrine disruption and analytical toxicology.  Students in the General Toxicology Option may conduct research in any area of Toxicology, but their coursework may reflect a broader base of knowledge than those within the other two subdisciplines.  For a list of faculty and a description of their research programs please visit our research page and click on the Environmental and Molecular Cellular links.

General Toxicology Course Requirements

Core course requirements for all Ph.D. students
TOX 701 Fundamentals of Toxicology (3 credits)
TOX 710 Molecular & Biochemical Toxicology (3 credits)
Tox 715 Environmental Toxicology (3 credits)
GN 701 Molecular Genetics (3 credits)
CBS 770 Cell Biology (3 credits)
ST 511(a) Experimental Statistics for Biological Sciences (3 credits)
TOX 801(b) Toxicology Seminar (1 credit/semester)
TOX 820 001 Responsibility in Science (1 credit)
TOX 820 003 Lab Rotation (1 credit/semester)
  1. Another graduate-level statistics course can be substituted with approval of the student’s committee
  2. Enrollment is required for each semester registered while in Doctoral Program (6 credits minimum)
Research requirements for all Ph.D. students
TOX 895 Doctoral Dissertation Research (6 credits minimum)
TOX 896 Summer Dissertation Research (as needed)
TOX 899 Doctoral Thesis Preparation (as needed)
Additional requirements for General Toxicology Concentration
GN 820 Professional Development (1 credit)
Electives 6 credits relevant to the student’s area of research must be selected

Normally a total of 72 credit hours is required, with the majority of these credits being dissertation research. See the 2016-2017 Handbook for specific credit hour and residency requirements.

Current Students and Recent Graduates in General Toxicology

Current and former students in General Toxicology provide the fuel (and the blood, sweat and tears) for advancing the science of toxicology. Listed below are the names of recent graduates in General Toxicology along with their thesis titles, the laboratories in which they conducted their doctoral research, and their current research positions. You will also find a list of current students and their areas of research and the laboratories in which they are studying. Feel free to contact any General Toxicology student for information about their specific research project, their laboratory, or the General Toxicology option. Complete contact information for all current students may be found on the People/Student page. Visit the Alumni section of our web to learn more about NC State University Toxicology graduates and possibilities for careers in toxicology.

Recent General Toxicology Graduates

Year Graduated Graduate Name & E-mail
Dissertation Title/Faculty Advisor
Current Position, Organization, Address,Postdoctoral Position
(if prior to current)
2017 Gina Hilton, PhD
Proteomic Investigation of Various Methods used for Carbon Nanotube Exposure. Mentors-M. Bereman and JC Bonner
People for the Ethical Treatment of Animals (PETA) International Science Corsortium
2016 Charisse Holmes, PhD
Influence of Environmental Chemicals on Regulatory Processes that Control Glucose and Lipid Homeostatis. Mentor-G. LeBlanc
Drug Safety Associate, PRA Health Sciences
2016 Melissa Pickett, PhD
A Novel Non-neuronal Functions of Acetylcholinesterase during the Development of the Intestine. Mentor-N. Nascone-Yoder
2014 Monica Poteat, PhD
Comparative trace metal physiology in aquatic insects. Mentor-D. Buchwalter
Medical Science Writer/Editor, Education & Training Systems International
2014 Erin Kollitz, PhD
Functional diversification of the vitaminD receptor (VDR) with increasing genome complexity in vertebrates. Mentor-SW KullmanBE
Postdoc, Duke University
2011 Huiying Zhang, PhD
The role of human sulfatase 1 in human lung injury and repair. Mentor-P Sannes
BE Configuration Analyst, BCBS of Louisiana
2009 Bethany Hannas, PhD
Mechanistic evaluation of the reproductive and developmental toxicity of nitrate and nitrite. Mentor-GA LeBlanc
Toxicologist, The Dow Chemical Company
2006 Chad Blystone, PhD
Conazole pesticide disruption of testicular steroidogenesis during different stages of male development. Mentor-GA LeBlanc
Toxicologist, NTP, NIEHS
2006 J. Michael Sanders, PhD
Mechanisms of toxicity of polybrominated diphenyl ethers. Mentor-Burka
Toxicologist, National Cancer Institute
2005 Wendy N. Jefferson, PhD
Neonatal exposure to the phytoestrogen, genistein alters ovarian differentiation and development. Mentors-Newbold & GA LeBlanc
Biologist, NIEHS
2003 Xueyan Mu, PhD
Anti-ecdysteroidalactivity and associated toxicity of environmental chemicals in the crustacean Daphnia magna. Mentor-GA LeBlanc
Study Director, Covance Laboratories, Inc.
Postdoctoral Fellow, US EPA
2003 Doug Anspaugh, PhD
Molecular genetics and enzyme regulation of epoxide hydrolases in the cabbage looper, Trichoplusia ni. Mentor-RM Roe
Consumer Safety Strategies Team Leader, BASF Corporation
Postdoctoral Fellow, US EPA
2002 Tara Lovekamp, PhD
Molecular mechanisms of mono-(2-ethlyhexyl)phthalate (MEHP) -induced ovarian toxicity. Mentors-GA LeBlanc & Davis
Sr. Clinical Trial Manager, Array BioPharma, Inc.
Postdoctoral, Medical College of Georgia
2002 Meredith L. Gooding, PhD
The role of steroid metabolism in TBT-induced Imposex in lliyanassa obsoleta. Mentor-GA LeBlanc
Ecologist, US EPA
Postdoctoral Fellow, University of Iowa
2002 Cynthia J. Wolf, PhD
Mechanisms through which an environmental antiandrogen, vinclozolin, induces malformations of the male rat reproductive tract. Mentors-GA LeBlanc & E Gray
Biologist, US EPA
Postdoctoral Fellow, US EPA
2001 Alicia Chaves, PhD
Exposure assessment in the developing world: A modeling approach applied to tropical banana plantations. Mentors-D Shea & R Leidy
Head, Nestle Quality Assurance Center-Orbe
2000 Scott C. Coleman, PhD
Comparative in vitro metabolism of chloracetamide herbicides and selected metabolites between rat and human liver microsomes. Mentors-E Hodgson & R Rose
Head, Nonclinical Development, Spero Therapeutics
2000 Jeffrey S. Gillette, PhD
Polychlorinated biphenyls:isomer-specific effects on enzyme induction and steroid hormone metabolism. Mentors-R Rose & E Hodgson
 Professor of Biology and Program Head of Medical Lab Technology, Virginia Western Community College
2000 Philip A. Poston, PhD
New methods for the analysis of mercury and brevetoxins in toxicology studies. Mentors-D Shea & R Leidy
Clinical Associate Professor, Laboratory Director and Consultant, University of Florida
2000 Shana R. Dalton, PhD
Herbicide metolachlor effects on liver and thyroid endocrinology compared with CYP2B1/2. Mentor-Meyer
Study Director, Covance Laboratories Inc.
Postdoctoral, University of Nebraska Medical Center
1999 Stephen E. Graham, PhD
Polycyclic aromatic hydrocarbons in Massachusetts Bay sediment: diagnostics, accumulation and source apportionment. Mentors-D Shea & R Leidy
Physical Scientist, US EPA
Postdoctoral, US EPA
1999 C. Edwin Garner, PhD
Dermal absorption of polychlorinated biphenyls (PCBs) and the effect of PCB metabolites on estrogen metabolism. Mentors-Matthews & R Leidy
Senior Director, Drug Development Luria Scientific Industries, Ltd.
1999 Vickie S. Wilson, PhD
Physiological consequences of xenobiotic induced alterations in hepatic testosterone biotransformation. Mentor- GA LeBlanc
Research Biologist, US EPA
Postdoctoral, US EPA
1999 Drew Luellen, PhD
Accumulation of PAHs and petroleum biomarkers in SPMDs and fish to discriminate petroleum sources. Mentors-D Shea & R Leidy
Research Scientist, Virginia Institute of Marine Science
1998 Jana Cherrington, PhD
Effects of boric acid on the developing vertebral column and ribs in the CD-1 mouse in utero. Mentors-S Branch & E Hodgson
1998 Chris Hofelt, PhD
Use of artificial substrates to monitor organic contamination in the aquatic environment. Mentor-D Shea
Regulatory Affairs Manager, BASF
1998 Louise Parks Saldutti, PhD
An investigation of the changes in steroid hormone metabolism and vitellogenin production as biomarkers of exposure and effect of endocrine disrupting chemicals. Mentor-GA LeBlanc
Research Scientist, Merck
Postdoctoral Fellow,US EPA
1998 Anne V. Weisbrod, PhD
Organochlorine exposure and potential effects in three northwest Atlantic whales. Mentor-D Shea
Principal Scientist, Global Product Stewardship, Procter & Gamble
1997 Robert Lange, PhD
Anthralin-induced oxidative stress modulates inflammatory cytokin gene expression in human eratinocytes and the BALS/c Mouse Ear. Mentor-RC Smart
Senior Research Investigator, Bristol-Myers-Squibb
1997 Mark Wolff, PhD
Characterization and comparative pharmacological stuies of a functional y-aminobutyric acid (GABA) receptor cloned from heliothis virescens(noctuidae: lepidoptera). Mentors- E Hodgson & C Chalmers
Senior Analytic Consultant, SAS Institute, Inc.
1997 Lisa Bain, PhD
Cellular trafficking of pesticides by glutathione-s-transferase mu and p-glycoprotein. Mentor- GA LeBlanc
Professor, Biological Sciences, Clemson University
1997 Kumar Penmetsa, PhD
Applications of capillary electrophoresis in pesticide analysis and toxicology studies. Mentors-D Shea & R Leidy
Director, Bristol-Myers Corp.
1996 George Woodall, PhD
Effects of dietary casein levels on the activation and metabolism of promutagens by rat hepatic S9, microsomes and cytosol. Mentor-Levi
Toxicologist, EPA
1996 Scott Knowles, PhD
Lead disrupts lipid metabolism in human, rodent and avian species: consequences for immune function and disease resistance. Mentors-Donaldson & RC Smart
Senior Research Scientist, AgResearch Ltd.
1996 Dong Ryu, PhD
Regulation of cytochrome P450 monooxygenase isozymes CYP1A1, CYP1A2 and CYP1B1 by piperonyl butoxide and acenaphthylene. Mentor-E Hodgson
Professor, Seoul National University
1996 Donna Grant, PhD
A comparison of the distribution, metabolism and excretion of two benzoylphenylurea pesticides, diflubenzuron and lufenuron in the rat and mouse. Mentor-Levi
Sr. Director, Pre-Clinical Operations, Regeneron Pharmaceuticals
1996 James Greg Falls, PhD
Hormonally regulated expression of flavin-containing monooxygenases (FMO) isozymes; cloning, sequencing and cDNA-expression in E.coli of a murine female-specific liver form, FM03. Mentor-E Hodgson
Senior Toxicologist, GlaxoSmithKline

Current General Toxicology Students

Year Enrolled Student Name
Research Area/Faculty Advisor & Laboratory
Education
2015 Sarah Park
Hoyo Lab
B.S. Environmental Health, University of Washington
2015 Megan Knuth
Kullman Lab
B.S. Environmental Science, Appalachian State University
2015 Adrian Green
Planchart/Mattingly Lab
B.S. General Microbiology, California State University
Prof./Other, Natural Sciences, Yuba College
M.S. Pharmacology, University California Davis
 2014  Kylie Rock
Patisaul Lab
 B.S. General Biology, St. Lawrence University
 2011 AtLee Watson
Kullman Lab
B.S. General Biology, UNC-CH