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Toxicology Seminar with Dr. Steve Roberts

March 22, 2022 @ 4:00 pm - 5:00 pm

Talk Title: “APOBEC3A-induced mutagenesis during cancer development and treatment”

Bio: Dr. Steven A. Roberts is an associate professor in the School of Molecular Biosciences at Washington State University in Pullman, WA where his lab studies mechanisms of mutagenesis during cancer development.  His interests in DNA damage, DNA repair, and mutation began during his Ph.D. research in the Department of Biochemistry and Biophysics at the University of North Carolina, Chapel Hill.  At UNC, Dr. Roberts worked with Dr. Dale Ramsden studying non-homologous end joining repair of DNA double strand breaks and discovered an AP lyase activity within the DNA end recognition protein, Ku.  Subsequently, he completed post-doctoral training with Dr. Dmitry Gordenin at the National Institute of Environmental Health Sciences, where he studied genomic distributions of damage-induced mutations in yeast model systems and human cancer.  This work characterized mechanisms of kataegis (or simultaneously induced clustered mutations) in yeast, identified it’s occurrence in human cancers, and attributed kataegis events in cancer to aberrant activity of APOBEC cytidine deaminases.  At WSU, Dr. Roberts’s group has contributed significant discoveries on the mechanisms leading to the APOBEC mutation signature in human cancers, including how these enzymes damage nuclear DNA, identifying APOBEC3A as a key enzyme causing the signature, and understanding how this type of mutagenesis is controlled.  Additionally, his lab has worked to develop methods to map the location of DNA base lesions at single nucleotide resolution to understand how DNA damage, DNA repair, and chromatin structure contribute to the formation mutation hotspots in cancers like melanoma.

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March 22, 2022
4:00 pm - 5:00 pm
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