Our laboratory studies the cellular and molecular mechanisms through which toxic environmental agents cause lung diseases such as pulmonary fibrosis, asthma, and mesothelioma. Research in our laboratory is funded by The National Insitute of Environmental Health Sciences (NIEHS) and the National Science Foundation (NSF) to address to the adverse of effects of engineered nanoparticles. Using a variety of in vitro cell culture and in vivo transgenic mouse models, we have identified novel mechanisms that mediate the progression of nanoparticle-induced lung diseases. Of particular interest is determining the pathogenic potential of nanomaterials in susceptible populations and individuals with pre-existing disease, especially asthma. We also seek to identify physical and chemical properties of nanomaterials that trigger fibrotic or allergic reactions in the lung in order to provide information for the design of safer nanomaterials.
Research Areas: lung fibrosis, asthma, nanotoxicology, metals, particles, fibers.
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