Intestinal malrotation occurs in as many as 1 in 500 human births (0.2% of the population) and poses significant risk for life-threatening complications in babies and children. No clear inheritance pattern has been identified for intestinal malrotation, suggesting a multifactorial etiology involving genetic, epigenetic and/or environmental causes.
Normal digestive anatomy is a consequence of the dramatic elongation, left-right asymmetric looping and rotation of the primitive gut tube during fetal development, but the cellular and molecular mechanisms underlying these events in gut morphogenesis are poorly understood.
Our lab employs chemical genetic strategies in amphibian embryos to investigate the mechanisms of digestive tract morphogenesis, understand the etiology of intestinal malrotation, and define the effects of chemicals and toxins on gut development.
- (1995) An inductive role for the endoderm in Xenopus cardiogenesisNascone, N. and M. Mercola | Development 121, 515-523
- (1996) Endoderm and cardiogenesis: new insightsNascone, N. and M. Mercola | Trends in Cardiovascular Medicine 6, 211-216
- (1997) Organizer induction determines left-right asymmetry in XenopusNascone, N. and M. Mercola | Developmental Biology 189, 68-78
- (1997) Two molecular models of initial left-right asymmetry generationLevin, M. and N. Nascone | Medical Hypotheses 49, 429-435
- (2000) The evolutionary relationships between the amphibian, avian and mammalian stomachsSmith, D., R.C. Grasty, C.J. Tabin, and N. Nascone-Yoder | Evolution and Development 2 (6), 348-359
- (2003) Left and right contributions to the Xenopus heart: implications for asymmetric morphogenesisGormley, J.P. and N. Nascone-Yoder | Development, Genes and Evolution 213, 390-398
- (2003) left-right asymmetric morphogenesis in the Xenopus digestive systemMuller, J.K., Prather, D. and N. Nascone-Yoder | Developmental Dynamics 228(4):672-82
- (2006) A role for retinoid signaling in left-right asymmetric digestive organ morphogenesisLipscomb, K.J., Sablyak, A.R., Schmitt, C.E., Yoder, J.A. and N. Nascone-Yoder | Developmental Dynamics 235(8):2266-75
- (2008) Ancestral variation and the potential for genetic accommodation in larval amphibians: implications for the evolution of novel feeding strategiesLedon-Rettig CC, Pfennig DW, Nascone-Yoder N | Evolution and Development 10(3):316-25
- (2009) Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangementsRachel A Reed, Mandy A Womble, Michel K Dush, Rhesa R Tull, Stephanie K Bloom, Allison R Morckel, Edward W Devlin, Nanette M Nascone-Yoder | Dev Dyn 238: 12. 3111-3125
- (2010) Direct activation of Shroom3 transcription by Pitx proteins drives epithelial morphogenesis in the developing gutMei-I Chung, Nanette M Nascone-Yoder, Stephanie A Grover, Thomas A Drysdale, John B Wallingford | Development 137: 8. 1339-1349
- Heterotaxin: A TGF-β Signaling Inhibitor Identified in a Multi-Phenotype Profiling Screen in Xenopus EmbryosDush, M.K., A.L. McIver, M.A. Parr, D.D. Young, J. Fisher, D.R. Newman, P.L. Sannes, M.L. Hauck, A. Deiters, N. Nascone-Yoder | Chem.Biol.2011.18:252-263.