Michael Cowley

Bio

Dr. Cowley’s laboratory investigates how the developmental environment impacts the epigenetic regulation of the genome and to understand the functional consequences of this for developmental and metabolic health.

Publications

• Epigenetic control of the imprinted growth regulator Cdkn1c in cadmium-induced placental dysfunction , EPIGENETICS (2022)
• Genomic map of candidate human imprint control regions: the imprintome , EPIGENETICS (2022)
• The imprinted gene Zac1 regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease , TOXICOLOGICAL SCIENCES (2022)
• Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome , HEPATOLOGY (2022)
• Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart , FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
• Transcriptomic, proteomic, and metabolomic analyses identify candidate pathways linking maternal cadmium exposure to altered neurodevelopment and behavior , SCIENTIFIC REPORTS (2021)
• Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing , NUCLEIC ACIDS RESEARCH (2020)
• Maternal cadmium exposure in the mouse leads to increased heart weight at birth and programs susceptibility to hypertension in adulthood , SCIENTIFIC REPORTS (2019)
• Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study , EPIGENETICS (2019)
• Effects of Cadmium Exposure on DNA Methylation at Imprinting Control Regions and Genome-Wide in Mothers and Newborn Children. , Environmental health perspectives (2018)