Bio

Dr. Cowley’s laboratory investigates how the developmental environment impacts the epigenetic regulation of the genome and to understand the functional consequences of this for developmental and metabolic health.

Publications

• Cadmium exposure during adolescence and young adulthood induces signatures of metabolic dysfunction-associated steatotic liver disease , Scientific Reports (2025)
• Dietary Iron Supplementation Protects Against Growth Restriction and Metabolic Dysfunction‐Associated Steatotic Liver Disease in Perinatal Cadmium‐Exposed Mice , FASEB BioAdvances (2025)
• Environmental Contaminants, Iron Deficiency, and Iron‐Deficiency Anemia: A Review of the Literature , Scientifica (2025)
• The effects of developmental cadmium exposure on health and disease , Disease Models & Mechanisms (2025)
• Grb7, Grb10 and Grb14, encoding the growth factor receptor-bound 7 family of signalling adaptor proteins have overlapping functions in the regulation of fetal growth and post-natal glucose metabolism , BMC Biology (2024)
• LncRNA Tuna is activated in cadmium-induced placental insufficiency and drives the NRF2-mediated oxidative stress response , Frontiers in Cell and Developmental Biology (2023)
• Epigenetic control of the imprinted growth regulator Cdkn1c in cadmium-induced placental dysfunction , Epigenetics (2022)
• Genomic map of candidate human imprint control regions: the imprintome , Epigenetics (2022)
• The imprinted geneZac1regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease , Toxicological Sciences (2022)
• Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome , Hepatology (2022)