Toxicology research spans an array of topics ranging from the molecular to population level consequences of toxicant exposure. A common research theme involves the understanding how toxicants/cellular stressors perturb signaling pathways/networks, deregulate gene expression and how this contributes to toxicity/disease at the cellular, organ and organism level. Linkage of adverse biological endpoints to toxicant exposure is a mechanistic goal. Some specific research areas include: endocrine disruption, trace metal bioaccumulation and detoxification, oxidative stress/gene regulation/cell toxicity, asthma and lung fibrosis, cancer and mutagenesis, ecotoxicology, developmental abnormalities, chemical exposure assessment and analytical toxicology. Model systems/organisms utilized include cultured cells, genetically engineered mice and non-mammalian model systems such Medaka, zebrafish and daphnids as well as field-collected invertebrate and fish. Examples of types of environmental agents that are being investigated include chemical carcinogens, trace metals, pesticides, particulates metals, endocrine disruptors, nanoparticles and UVB radiation. Specific interests of the faculty are described in research faculty pages grouped according to the major research focus: Molecular and Cellular or Environmental.
A weekly research seminar series provides a forum for invited scientists and graduate students/postdocs to present and discuss their research. Each semester a former student is invited back to present a seminar and to share their career experiences with current students and postdocs.
Collaborations with associate and adjunct faculty expand the breadth of the research and learning opportunities. Associate faculty members are housed in a variety of departments located in the College of Science, Colleges of Agriculture and Life Sciences, Veterinary Medicine, and Natural Resources. Adjunct faculty members are located at institutions within the Research Triangle Park (RTP) area such as the National Institute of Environmental Health Sciences (NIEHS), Environmental Protection Agency (EPA), the Hamner Institute (formally CIIT) and Glaxo Smith-Kline (GSK).